Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives

Biological activity of amide derivatives of lysine.

Five substituted amides of lysine with the general formula: X-Lys-NH-Y, where X= acetyl or ethoxycarbonyl, Y= cyclohexyl, benzyl, hexyl or cadaverine residue were synthesised and their effects on fibrinolytic activity of plasmin, clotting activity of thrombin and amidolytic activities of both enzymes were examined.

Biomanufacturing In Industrial Engineering

Biotechnology has become one of the primary technology development areas of the 21 century. For a medical device or pharmaceutical manufacturer to remain on the competitive edge, not only is it necessary to satisfy the stringent demands of the biotechnology markets, but those companies must also develop processes that can accelerate the time frame from research and development to manufacturing ...

Fragmentation Studies of Lysine and Lysine Analog Containing Tetrapeptides

Gramicidin A disassembles large conductive clusters of its lysine-substituted derivatives in lipid membranes.

N-terminally substituted lysine derivatives of gramicidin A (gA), [Lys1]gA and [Lys3]gA, but not glutamate- or aspartate-substituted peptides have been previously shown to cause the leakage of carboxyfluorescein from liposomes. Here, the leakage induction was also observed for [Arg1]gA and [Arg3]gA, while [His1]gA and [His3]gA were inactive at neutral pH. The Lys3-containing analogue with all t...

The L-Lysine Story: FromMetabolic Pathways to Industrial Production

l-lysine is an essential amino acid required for nutrition of animals and humans. It has to be present in food and feed, which, in many cases, is realized by supplementation of the feed-stuffs with pure lysine. The high importance of lysine in nutrition has stimulated intensive research on the lysine biosynthetic pathways and their regulation and the search for microorganisms capable of over-pr...